The Evans lab focuses on a small group of vertebrate transcriptional regulatory proteins called GATA factors. These proteins function to regulate a variety of cell differentiation programs during embryogenesis and throughout life. We are particularly interested in the embryonic signaling programs that regulate the genes encoding GATA factors, including the Bone Morphogenetic Proteins (BMPs). There are two major programs in the lab, studying erythropoiesis (red blood cell development) and cardiogenesis (heart development). We take advantage of a number of embryonic experimental systems, including frogs, zebrafish, and chicks. We are also involved in collaborative studies using mammalian systems to understand the role of GATA factors in various disease
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